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. 2011 Mar 8;104(7):1106–1115. doi: 10.1038/bjc.2011.78

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Copyright © 2011 Cancer Research UK

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Therapeutic activity of SIP(L19)–PS. (A) Nude mice bearing subcutaneous F9 teratocarcinomas were injected intravenously with 150 μg of SIP(L19)–PS (⧫ and •), SIP(F16)–PS (▴) or saline (▪) on days 0, 2, 4 and 6 of the treatment schedule, and tumours were irradiated daily with 60 J cm⁻² from days 1 to 8 (⧫, ▴ and ▪) or not irradiated at all (•); ^*P<0.01 vs not irradiated, ^**P<0.01 vs saline. (B) Nude mice bearing subcutaneous F9 teratocarcinomas were injected with 150 μg of SIP(L19)–PS (⧫ and •) or saline (▪) on days 0, 2 and 4, and tumours were irradiated daily with 60 J cm⁻² from days 1 to 6. Mice in one of the groups receiving PS conjugate were depleted of NK cells by injections of 0.3 mg of an anti-asialo-GM1 antibody every 5 days during therapy, starting at day −1 of the therapy regimen (•). CR, complete response. hν, irradiation.