Table 2. Medication, dose adjustments and delays.
Gemcitabine and Vinorelbine | Gemcitabine and Cisplatin | Gemcitabine and Capecitabine | ||||
---|---|---|---|---|---|---|
Number of cycles applied | ||||||
Total | 200 | 190 | 207 | |||
Median/patient completed (range) | 6.0 | (1–8) | 4.5 | (1–8) | 5.0 | (1–8) |
N | % | N | % | N | % | |
Doses reduced, delayed or both | ||||||
Day 1 | 52 | 26.0 | 57 | 30.0 | 56 | 27.1 |
Day 8 | 56 | 28.0 | 58 | 30.5 | 61 | 29.5 |
Dose omitted | ||||||
Day 1 | 1 | 0.5 | ||||
Day 8 | 17 | 8.5 | 27 | 14.2 | 9 | 4.4 |
Dose intensity gemcitabine | ||||||
Planned dose (mg m−2 per week) | 666.7 | 666.7 | 666.7 | |||
Actual median dose (mg m−2 per week) (range) | 600.0 | (307–684) | 541.6 | (309–679) | 618.7 | (274–698) |
Relative dose intensity (actual/planned × 100) | 90.0 | (46–103) | 81.2 | (46–102) | 92.8 | (41–105) |
Dose intensity second substance | ||||||
Planned dose (mg m−2 per week) | 16.7 | 20.0 | 6066.7 | |||
Actual median dose (mg m−2 per week) (range) | 15.0 | (7–17) | 16.3 | (9–20) | 5702.0 | (2885–7778) |
Relative dose intensity (actual/planned × 100) | 90.0 | (42–104) | 81.3a | (46–101) | 94.0a | (48–128) |
Statistical significant (P=0.0003) by Fishers exact test.