Table 2. Medication, dose adjustments and delays.
| Gemcitabine and Vinorelbine | Gemcitabine and Cisplatin | Gemcitabine and Capecitabine | ||||
|---|---|---|---|---|---|---|
| Number of cycles applied | ||||||
| Total | 200 | 190 | 207 | |||
| Median/patient completed (range) | 6.0 | (1–8) | 4.5 | (1–8) | 5.0 | (1–8) |
| N | % | N | % | N | % | |
| Doses reduced, delayed or both | ||||||
| Day 1 | 52 | 26.0 | 57 | 30.0 | 56 | 27.1 |
| Day 8 | 56 | 28.0 | 58 | 30.5 | 61 | 29.5 |
| Dose omitted | ||||||
| Day 1 | 1 | 0.5 | ||||
| Day 8 | 17 | 8.5 | 27 | 14.2 | 9 | 4.4 |
| Dose intensity gemcitabine | ||||||
| Planned dose (mg m−2 per week) | 666.7 | 666.7 | 666.7 | |||
| Actual median dose (mg m−2 per week) (range) | 600.0 | (307–684) | 541.6 | (309–679) | 618.7 | (274–698) |
| Relative dose intensity (actual/planned × 100) | 90.0 | (46–103) | 81.2 | (46–102) | 92.8 | (41–105) |
| Dose intensity second substance | ||||||
| Planned dose (mg m−2 per week) | 16.7 | 20.0 | 6066.7 | |||
| Actual median dose (mg m−2 per week) (range) | 15.0 | (7–17) | 16.3 | (9–20) | 5702.0 | (2885–7778) |
| Relative dose intensity (actual/planned × 100) | 90.0 | (42–104) | 81.3a | (46–101) | 94.0a | (48–128) |
a
Statistical significant (P=0.0003) by Fishers exact test.