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A low dose of pioglitazone (PGT) normalized the expression of the fibrosis marker, connective tissue growth factor (CTGF), in renal tissue in type 2 diabetic rats. a–c Representative micrographs of renal tissue subjected to immunostaining. ×400. Arrows indicate overexpression of CTGF. a ZDF (Zucker diabetic fatty); b ZDF treated with PGT; c LZR (lean Zucker rats). d Bar graph representing the percentage of positive staining in all groups. e Western blot bands and densitometry.
