Fig. 6.

A low dose of pioglitazone (PGT) normalized the expression of an angiogenesis marker, vascular endothelial growth factor (VEGF), in this case denoting abnormal angiogenesis, in renal tissue in type 2 diabetic rats. a–c Representative micrographs of renal tissue subjected to immunostaining. ×400. Arrows indicate expression mainly in epithelial tubular cells. a ZDF (Zucker diabetic fatty); b ZDF treated with PGT; c LZR (lean Zucker rats). d Bar graph representing the percentage of positive immunostaining in all groups. e Western blot and densitometric estimations.