Table 1.
Body weight, blood pressure and laboratory parameters
| |||
|---|---|---|---|
| ZDF (n = 8) | ZDF + PGT (n = 8) | LZR (n = 8) | |
| Body weight, g | 397.1 ±20.0 | 400.7 ±18.2 | 265.9 ±15.9∗ |
| Systolic blood pressure, mm Hg | 122.5 ±2.8 | 122.8 ±3.5 | 120.2 ±3.3 |
| Diastolic blood pressure, mm Hg | 75.4 ±2.1 | 74.9 ±2.2 | 73.5 ±1.9 |
| Glycemia, mg/dl | 395.6 ±40.6 | 404.5 ±35.1 | 96.0 ±14.4∗ |
| Serum insulin, ng/ml | 38.6 ±5.9 | 37.3 ±5.2 | 5.1 ±0.9∗ |
| Triglycerides, mg/1 | 598.8 ±45.9 | 601.3 ±55.7 | 35.9 ±9.7∗ |
| Cholesterol, mg/1 | 145.7±20.1 | 153.3 ±18.7 | 55.6 ±4.8∗ |
| Creatinine clearance, ml/min | 3.2 ±0.4 | 3.1 ±0.5 | 3.0 ±0.3 |
| Proteinuria, mg/day | 18.3 ±5.0 | 20.3 ±4.2 | 2.3 ±0.1∗ |
| |||
| Body weight, g | 502.6 ±14.3 | 484.2 ±16.4 | 396.9 ±20.2∗ |
| Systolic blood pressure, mm Hg | 160.5 ±5.1 | 134.1 ±4.2∗∗ | 123.8 ±3.7∗ |
| Diastolic blood pressure, mm Hg | 96.0 ±2.8 | 81.8 ±2.3∗∗ | 74.1 ±2.2∗ |
| Glycemia, mg/dl | 475.6 ±50.2 | 243.3 ±30.7∗∗ | 115.8± 10.5∗ |
| Serum insulin, ng/ml | 8.8 ±3.1 | 10.1 ±2.8 | 3.4 ±1.2∗ |
| Triglycerides, mg/1 | 587.3 ±59.4 | 223.6 ±21.6∗∗ | 39.5 ±8.4∗ |
| Cholesterol, mg/1 | 176.5 ±23.1 | 95.2 ±10.6∗∗ | 57.2 ±4.6∗ |
| Creatinine clearance, ml/min | 2.2 ±0.2∗ | 2.9 ±0.3 | 3.0 ±0.2 |
| Protein uria, mg/day | 234.1 ±30.2 | 56.3 ±9.1∗∗ | 7.3 ±2.5∗ |
Values are mean ± SD.
∗
p < 0.01 vs. all groups.
∗∗
p < 0.01 vs. ZDF. PGT = Pioglitazone.