Table 2. Protective index (PI) values of sodium valproate and Nigella sativa seed constituents against MES- PTZ-induced convulsions.
Treatment | SVP | AE | FO | VO | TQ (CMC) | AP | PC |
---|---|---|---|---|---|---|---|
PTZ model PI = TD50/ED50 |
1.13 | 0.48 | < 0.22 | 0.81 | 0.95 | < 0.39 | 0.93 |
MES model PI = TD50/ED50 |
1.07 | _ | _ | 0.43 | _ | _ | 0.34 |
SVP = Sodium valproate, AE = Aqueous extract, FO = Fixed oil, VO = Volatile oil, TQ = Thymoquinone, AP = α-pinene, PC = p-cymene.