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. 2009 Jul;3(2):177–186.

Table (5).

Relationship between METAVIR activity & fibrosis scores and laboratory data in patients CHC with elevated enzymes.

Laboratory Data METAVIR (activity) (A) METAVIR (staging) (F)
r p r p
FBG 0.80 0.01** 0.43 0.02*
FI 0.38 0.1* 0.60 0.01**
HOMA-IR 0.49 0.02* 0.66 0.01**
PCR 0.41 0.031* 0.32 0.22
ALT 0.42 0.04* 0.40 0.04*
PT 0.87 0.01** 0.49 0.01**

In CHC patients with normal liver enzymes; FBG & HOMA-IR were correlated with METAVIR activity and liver fibrosis scores in table (6) & figure (4) (p=0.04, 0.01 and p=0.01, 0.02 respectively) while viral load (PCR) was correlated with METAVIR activity score only (p=0.031) and prothrombin time was correlated with METAVIR fibrosis score (p=0.02). There is a correlation between serum fasting insulin and liver fibrosis progression in CHC patients with elevated enzymes (p=0.01) table (5) and in those with normal enzymes (p=0.02) (table-6).