Table 1.
Potency of carbachol (CCh) and isoprenaline (IPNA) in transverse (Tr) and longitudinal (Lg) detrusor strips from control and Tianma-treated rats. CCh-induced contractions and IPNA-induced relaxations of urothelium-intact (+UE) and urothelium-denuded (−UE) strips were examined. Potency is expressed as the logarithms of the CCh or IPNA concentration achieving 50 % maximal efficacy. * denotes P < 0.05 vs. control.
| CCh |
IPNA |
||||
|---|---|---|---|---|---|
| Control | Tianma-treated | Control | Tianma-treated | ||
| Tr | +UE | -6.5 ± 0.2 | -6.1 ± 0.1 | -6.3 ± 0.2 | -6.2 ± 0.1 |
| -UE | -6.3 ± 0.2 | -6.1 ± 0.1 | -6.4 ± 0.1 | -6.3 ± 0.2 | |
| Lg | +UE | -6.2 ± 0.1 | -6.0 ± 0.2 | -6.3 ± 0.1 | -5.8 ± 0.1* |
| -UE | -6.3 ± 0.2 | -6.1 ± 0.1 | -6.37 ± 0.09 | -6.2 ± 0.1 | |