Figure 5.

Effect of Rosuvastatin (10 nM) on NO production in cortical neurons exposed to OGD/reoxygenation. The cells were pre-treated with RSV for 24 hrs and, after OGD/reoxygenation, NO production was assayed by the Griess method. Data are expressed as a percentage + SEM vs control untreated cells. *P<0.05 vs its respective control group; **P<0.05 vs OGD/Rx group. B. Effect of NPLA and PD98059 on survival of cortical neurons exposed to OGD/reoxygenation in the presence of Rosuvastatin. Cortical neurons were pre-treated for 24 hrs with RSV (10 nM) and with NPLA (5 nM) or with PD98059 (40 μM) in the culture medium and then exposed to OGD/reoxygenation. At the end of the treatments mitochondrial oxidative capacity was evaluated by MTT assay. Data are expressed as a percentage +SEM vs. control untreated cells. *P<0.05 vs its respective control group; **P<0.05 vs RSV treated group; #P<0.05 vs OGD/Rx group; ##P*<0.05 vs OGD/Rx + RSV group