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S1P2R does not desensitize the C5aR. Intracellular calcium was measured in cell suspensions of WT macrophages loaded with fura 2, as described in Materials and Methods. Cells were sequentially stimulated with 1 nM C5a (A) or stimulated with 1 μM S1P, followed by 1 nM C5a (B), and intracellular calcium content measured in real time.
