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Respiratory tract exposure boosts serum levels of MDI-specific antibodies elicited by primary skin exposure. Serum levels of MDI-specific antibodies from mice (with (+) or without (-) prior skin exposure) following respiratory tract exposure to MDI albumin conjugates (+) or mock exposed albumin (-). Each bar represents the mean ± SEM for 12 mice; * p < .001 comparing skin exposed vs. skin + airway exposed
