The SUR1 transgene is specifically expressed in forebrain structures as
indicated by in situ hybridization. Autoradiographic
film exposures of sagittal sections of brain from a WT
(A) and a Tg174 mouse (B) show enhanced
message expression in layers II, III, and VI of the cerebral cortex
(CTX), striatum (ST), and hippocampus (HP), but not the cerebellum or
midbrain structures. Closer examination of the hippocampus using
autoradiographic emulsion exposures from a WT (C) and a
Tg174 mouse (D) indicate high levels of expression in
the pyramidal neuron layer and dentate gyrus. Magnification: ×50.