Skip to main content
. 2001 Feb 27;98(6):3549–3554. doi: 10.1073/pnas.051012898

Figure 4.

Figure 4

Hippocampal pyramidal neurons from SUR1 Tg174 mice are resistant to KA-induced excitotoxicity. Reconstruction of the dentate gyrus (A) and the pyramidal neuron layer (B) of the hippocampus using morphometric analysis of cresyl violet-stained sections of the entire hippocampus allowed the determination and comparison of pyramidal neuron layer volumes. Volume decreased in the pyramidal neuron layer of the WT + KA group (B), but no significant decrease in dentate gyrus volume (A) was observed after KA administration to any of the mice (WT, TG174, TG166 + KA). Manual counts of pyramidal neurons in the CA1, CA2, and CA3 subfields revealed a significant loss of neurons in the WT + KA group CA1, CA2, and CA3, and the CA2 and CA3 from the TG166 + KA group. However, there was no significant neuronal loss observed in mice from the Tg 174 + KA group. *, Significantly different from control (WT + saline), P < 0.05, ANOVA followed by Tukey's multiple comparison test. (A), Significantly different from WT + KA group, P < 0.05, ANOVA followed by Tukey's multiple comparison test.