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. 2011 Mar 31;6(3):e18233. doi: 10.1371/journal.pone.0018233

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Wang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Schematic representation of gp41 and NCMs. The gp41 molecule consists of fusion peptide (FP), N-terminal heptad repeat (NHR), loop (immunodominant) region, C-terminal heptad repeat (CHR), membrane-proximal external region (MPER), and cytoplasm tail (CT). (B) The amino acid sequences of NCMs. The sequence of N36 and C34 are in brown and blue, respectively. The epitopes for 2F5 (ELDKWA) and 4E10 (NWFDIT) are highlighted in red and green, respectively. The mutations of T569A and I675V are in boldface. (C) NCMs may form 6HB with exposed MPER tails. The epitopes for 2F5 and 4E10 are in red and green, respectively. (D) SDS-PAGE analysis of purified NCMs. The estimated molecular weight of NCMs is 11.8 kD. (E) Chemical cross-linking assay of NCM. NCM(IV), NCM(TA) and NCM(TAIV) showed similar results (data not shown).