Table 1. The immunogenicity of NCMs after the third immunization.
Group | Immunogen | Rabbit | Titers of antibodies specific for | ||
No | Immunogen | MPER peptide | MPER (IV) peptide | ||
I | NCM | 1 | 1∶4×105 | <1∶400 | <1∶400 |
2 | 1∶1×105 | 1∶1600 | 1∶800 | ||
3 | 1∶1×105 | <1∶400 | <1∶400 | ||
Geometric mean titer | 1∶1.6×105 | 1∶635 | 1∶504 | ||
II | NCM(IV) | 4 | 1∶1×105 | 1∶800 | 1∶800 |
5 | 1∶4×105 | 1∶3200 | 1∶3200 | ||
6 | 1∶4×105 | 1∶400 | 1∶400 | ||
Geometric mean titer | 1∶2.5×105 | 1∶1008 | 1∶1008 | ||
III | NCM(TA) | 7 | 1∶1×105 | 1∶1600 | 1∶800 |
8 | 1∶1×105 | <1∶400 | <1∶400 | ||
9 | 1∶4×105 | 1∶3200 | 1∶3200 | ||
Geometric mean titer | 1∶1.6×105 | 1∶1270 | 1∶1008 | ||
IV | NCM(TAIV) | 10 | 1∶4×105 | 1∶12800 | 1∶12800 |
11 | 1∶4×105 | 1∶25600 | 1∶25600 | ||
12 | 1∶4×105 | 1∶25600 | 1∶12800 | ||
Geometric mean titer | 1∶4×105 | 1∶20319 | 1∶16127 |
Note: “<1∶400” was treated as 1∶400 when the Geometric mean titer was calculated.