Table 2. Profile of serotonin metabolites in brain of WT and R6/2 mice at 4, 8 and 12 weeks of age.

GENOTYPE	Age	REGION	N	5-HT	5-HIAA	5-HT/5-HIAA
	(weeks)			(nmol/g)	(nmol/g)
R6/2	4	Striatum	17	6.14±1.19**	1.27±0.36**	0.206±0.042**
WT			18	7.34±1.14	2.26±0.35	0.311±0.045
R6/2	4	Hippocampus	17	6.12±0.87**	1.26±0.31**	0.206±0.044**
WT			18	8.38±1.32	2.47±0.41	0.300±0.059
R6/2	4	Frontal Cortex	16	6.57±1.24**	0.65±0.23**	0.099±0.024**
WT			17	8.51±0.86	1.13±0.17	0.133±0.019
R6/2	8	Striatum	15	5.67±0.79**	0.48±0.11**	0.085±0.017**
WT			15	10.16±1.73	2.61±0.56	0.259±0.045
R6/2	8	Hippocampus	15	5.23±0.71**	0.45±0.12**	0.085±0.020**
WT			15	11.88±2.10	3.03±0.72	0.257±0.048
R6/2	8	Frontal Cortex	15	6.75±1.19**	0.22±0.05**	0.033±0.005**
WT			14	12.32±1.69	1.33±0.23	0.110±0.027
R6/2	12	Striatum	18	4.85±1.30**	0.39±0.12**	0.082±0.015**
WT			15	9.14±2.47	2.46±0.60	0.275±0.046
R6/2	12	Hippocampus	18	5.40±1.11**	0.44±0.16**	0.082±0.023**
WT			16	12.02±2.27	3.30±0.77	0.278±0.055
R6/2	12	Frontal Cortex	18	6.86±1.19**	0.27±0.18**	0.041±0.028**
WT			15	11.86±2.01	1.49±0.24	0.128±0.025

**p<0.001 compared to WT mice.