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. Author manuscript; available in PMC: 2012 Apr 6.
Published in final edited form as: J Am Chem Soc. 2011 Mar 14;133(13):4785–4787. doi: 10.1021/ja200766k

Chart 1.

Chart 1

Reaction scope.a

a Conditions: 1 (0.3 mmol), 2 (1.25 equiv), [Rh(C2H4)2Cl]2 (5 mol %), and L2 (10 mol %) in PhMe at 110 °C for 12 h. b Isolated yield. c Enantiomeric excess determined by HPLC using a chiral stationary phase. d Absolute configuration assigned by analogy to (R)-3af (established by X-ray analysis – see SI). e On 4.5 mmol scale with [Rh(C2H4)2Cl]2 (1 mol %) and L2 (2 mol %): 71% yield and 94% ee.