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. Author manuscript; available in PMC: 2012 Apr 6.
Published in final edited form as: J Am Chem Soc. 2011 Mar 14;133(13):4785–4787. doi: 10.1021/ja200766k

Table 1.

Catalyst Screen.a

graphic file with name nihms-280782-t0002.jpg
entry catalyst yield (%)b ee (%)c,d
1 none 0 -
2 Ni(cod)2 (10 mol %), TMEDA (10 mol %) 0 -
3 Rh(PPh3)3Cl (10 mol %) <5 -
4 [Rh(C2H4)2Cl]2 (5 mol %), L1 (10 mol %) 29 81
5 [Rh(C2H4)2Cl]2 (5 mol %), L2 (10 mol %) 56 90
6 [Rh(C2H4)2Cl]2 (5 mol %), L3 (10 mol %) 22 79
7 L2 (10 mol %) 0 -
graphic file with name nihms-280782-t0003.jpg
a

Conditions: 1 (0.3 mmol), 2 (1.25 equiv), and catalyst in PhMe at 110 °C for 12 h.

b

Isolated yield.

c

Enantiomeric excess determined by HPLC using a chiral stationary phase.

d

Absolute configuration assigned by analogy to (R)-3af (established by X-ray analysis – see SI).