Fig. 2.

Platensimycin preferentially distributes to the liver following oral dosing (n = 3) (A) and inhibits fatty acid synthesis in the liver, but not in adipose tissue (WAT) (n = 5) (B). db/db mice were used. For A, PTM was dosed orally at 100 mpk; for B, PTM was administered via i.p. injection at the doses indicated. Lower limits of detection were 0.0045, 0.045, and 0.009 μM for plasma, brain, and liver. For fatty acid synthesis measurements, the [³H]H₂0 incorporation method was used.