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. 2011 Mar 14;108(13):5396–5401. doi: 10.1073/pnas.1007811108

Fig. 2.

Fig. 2.

Intestinal epithelial TNF overexpression leads to Crohn-like IBD pathology. Histological examination of the ileum of VillinCreTnfΔAREneo/+ mice (A–C) and littermate controls (D–F). (A) Two-month-old VillinCreTnfΔAREneo/+ mice appear normal with no signs of inflammatory infiltration. (B) Severe pathology in a 4-mo-old VillinCreTnfΔAREneo/+ mouse characterized by massive inflammatory infiltration in the intestinal mucosa and submucosa. Intestinal villi are broadened and blunted. (C) Extensive submucosal and transmural inflammation in an 8-mo-old VillinCreTnfΔAREneo/+ mouse. (D) WT, (E) VillinCre, and (F) TnfΔAREneo/+ littermate control mice are normal with no signs of intestinal inflammation at age 8 mo. Paraffin sections were stained with H&E. (Scale bars: 100 μm.) (G) Disease score distribution in the ileum of VillinCreTnfΔAREneo/+ and littermate mice at age 2 mo (*P < 0.05), 3 mo (***P < 0.001), 4 mo (***P < 0.001), and 8 mo (***P < 0.001).