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. 2011 Mar 14;108(13):5342–5347. doi: 10.1073/pnas.1013054108

Fig. 4.

Fig. 4.

Precocious anagen entry in Rank-Tg mice and in response to recombinant RANKL. (A) At P24, WT mice HFs are in anagen II/IIIa, whereas HFs of Rank-Tg mice are already in anagen IIIc. (Scale bars, 100 μm.) (B) At P56, WT mice HFs are in telogen, whereas HFs of Rank-Tg mice are in anagen IV/V. (Scale bars, 100 μm.) (C) Schematic representation of hair morphogenesis and the hair-cycle telogen-to-anagen transitions in Rank-Tg and control mice. Red arrow points to P24 and blue arrow points to P56, corresponding to images in A and B. (D) At 8 wk, WT mice received two s.c. injections of 100 μg of RANKL-GST or control GST with a 12-h interval. Then, 6 d later, their back skin was analyzed for anagen. Graphic representation that three of four treated mice precociously entered anagen, in contrast to control mice remaining in telogen. (E) Image of HFs in anagen of a RANKL-GST–treated mouse, whereas they are in telogen in the GST control mouse. (Scale bars, 100 μm; in Inset, 50 μm.) The paraffin-embedded sections were stained with hematoxylin/eosin.