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Adhesion of control (A) and SCD (B) neutrophils to HUVEC in the presence of simvastatin. Neutrophils from control individuals (n=8) or SCD patients (n=11) were allowed to adhere to HUVEC or to TNF-α-stimulated HUVEC cells in the presence or not of 1 μM simvastatin (SIM) or 1 μM simvastatin and 1 mM L-NAME (SIM+L-N, n=6). ***P<0.001, TNF-α compared to basal adhesion; ••P<0.01 compared to TNF-α alone; ≈≈P<0.01 compared to TNF/SIM; Friedman’s test, followed by Dunn’s multiple comparison.
