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. 2010 Dec 20;96(4):526–533. doi: 10.3324/haematol.2010.032912

Figure 5.

Figure 5.

Effect of simvastatin on TNF-α-stimulated expression of ICAM-1 (A) and VCAM-1 (B) on HUVEC. HUVEC were stimulated, or not, with TNF-α (10 ng/mL; for 3 h) following their pre-incubation (or not) with 1 μM simvastatin (Sim). Surface ICAM-1 and VCAM-1 expression was determined by flow cytometry using an anti-CD54 phycoerythrin antibody and anti-CD106 fluorescein isothiocyanate, respectively. Data are expressed as mean MFI±SEM (n=4) for ICAM-1 (A) and % positive cells ± SEM (n=4) for VCAM-1 (B). *P<0.05; **P<0.01, ***P<0.001, compared to basal adhesion. ##P<0.01 compared to TNF-α alone. Repeated measures analysis, followed by Bonferroni’s test.