Fig. 3.

Top the dedicated rat brain electrode device: four parallel inner electrodes and four angled outer electrodes of 0.2 mm diameter each. The diagonal tip distances of inner and outer electrodes are 2.3 and 5.2 mm, respectively. The electrodes have a Pd core and a shell made of 35N LT^® (Forte Wayne Metals, Fort Wayne, IN). Bottom top view of the electrode positions and the electric field distribution at one particular polarity configuration. White and black dots correspond to opposing polarities. The configuration is “rotated” 90° three times to cover the target tissue, and eight full revolutions are required to complete the EP procedure. The electric field distribution is for the plane perpendicular to the inner electrode plane halfway in the conducting part and shows that the average electric field strength is about 1,000 V/cm in the targeted area, when the high-voltage condition (200 V) is applied