Figure 8.

Gd-DO3A-based MRI CA. (a) with a Cu⁺-binding thioether pendant arm demonstrating; (b) r ₁ relaxivity increases (with corresponding percent increase given) to 1 equiv. of Cu⁺ in the presence of various biological anions. White bars represent CA relaxivities in the absence of Cu⁺ while the black bars represent relaxivities with addition of Cu⁺ (60 MHz, 37 °C, pH = 7.4); (c) shows the Cu²⁺ activated CA. Graph from Fig. 7 in Que et al. 65