Table 1.
Results of Follow-Up Testing of INSTITM Non-Reactive or Indeterminate Early HIV Sero-Conversion Specimens
| Case # | Initial Specimensa | Follow-Up Specimensb | ||||
|---|---|---|---|---|---|---|
| Siemens ADVIA Centaur EIA (Signal/Cutoff) | Siemens ADVIA Centaur EIA Result | INSTITM Result | Siemens ADVIA Centaur EIA Result | INSTITM Result | Days From Initial to INSTITM Reactive Followup Specimend | |
| 3 | 0.8 | NR | NR | R | R | 49 |
| 6 | 0.8 | NR | NR | R | R | 251 |
| 18 | <0.05 | NR | NR | R | R | 16 |
| 33 | <0.05 | NR | NR | R | R | 15 |
| 2 | 1.9 | R | Indet | NT | R | 29 |
| 4 | 23.2 | R | Indet | R | R | 88 |
| 29 | 18.5 | R | Indet | R | R | 16 |
| 30 | 17.3 | R | Indet | R | R | 13 |
| 51 | 1.0 | R | Indet | NT | R | 20 |
| 7 | 4.0 | R | NR | R | NSQ | |
| 9 | 10.4 | R | NR | R | R | 42 |
| 11 | 8.1 | R | NR | R | R | 73 |
| 21 | >50 | R | NR | R | R | 26 |
| 25 | 1.3 | R | NR | R | NSQ | |
| 31 | 41.0 | R | NR | R | R | 8 |
| 37 | 13.8 | R | NR | R | R | 8 |
| 49 | 2.5 | R | NR | R | R | 22 |
| 57 | 1.2 | R | NR | R | Rc | 12 |
| 60 | 3.3 | R | NR | R | R | 7 |
NR=non-reactive; R=reactive; Indet=indeterminate; NSQ=insufficient quantity; NT=not tested.
a
All specimens were HIV-1 p24 antigen confirmed reactive.
b
All specimens were HIV-1 Western Blot positive.
c
A follow-up specimen collected 7 days after the initial specimen was INSTITM indeterminate.
d
Mean and median times from initial to INSTITM reactive follow-up specimen are 41 and 20 days, respectively.