Table 5.
Predictors of progression to combined endpoints of commencement of dialysis or death using Cox proportional hazards model
| Parameter | Univariate |
Multivariate (Forward) |
||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| Age (per 1 year) | 1.030 (0.990 to 1.072) | 0.138 | — | — |
| Male versus female | 0.851 (0.365 to 1.983) | 0.708 | — | — |
| Smoking (ever versus never) | 1.354 (0.597 to 3.070) | 0.468 | — | — |
| Diabetes mellitus | 1.438 (0.604 to 3.420) | 0.411 | — | — |
| Hypertension | 1.094 (0.245 to 4.889) | 0.906 | — | — |
| Coronary artery disease | 1.876 (0.769 to 4.579) | 0.167 | — | — |
| Cerebrovascular disease | 4.086 (1.681 to 9.933) | 0.002 | — | — |
| Heart rate (per 1 beat/min) | 1.019 (0.991 to 1.048) | 0.190 | — | — |
| Body mass index (per 1 kg/m2) | 0.918 (0.826 to 1.021) | 0.114 | — | — |
| Laboratory parameters | ||||
| albumin (per 1 g/dl) | 0.308 (0.108 to 0.882) | 0.028 | — | — |
| fasting glucose (log per 0.1 mg/dl) | 1.247 (0.976 to 1.594) | 0.077 | — | — |
| triglyceride (log per 0.1 mg/dl) | 1.039 (0.880 to 1.225) | 0.653 | — | — |
| HDL-cholesterol (per 1 mg/dl) | 0.979 (0.944 to 1.016) | 0.264 | — | — |
| LDL-cholesterol (per 1 mg/dl) | 0.987 (0.974 to 0.999) | 0.041 | — | — |
| hematocrit (per 1%) | 0.843 (0.786 to 0.905) | <0.001 | — | — |
| baseline eGFR (per 1 ml/min per 1.73 m2) | 0.873 (0.823 to 0.926) | <0.001 | 0.918 (0.862 to 0.977) | 0.007 |
| calcium (per 1 mg/dl) | 0.587 (0.399 to 0.865) | 0.007 | — | — |
| phosphate (per 1 mg/dl) | 2.108 (1.552 to 2.863) | <0.001 | 1.883 (1.183 to 2.997) | 0.008 |
| uric acid (per 1 mg/dl) | 1.066 (0.893 to 1.273) | 0.476 | — | — |
| PTH (log per 0.1 pg/ml) | 1.149 (1.043 to 1.265) | 0.005 | — | — |
| Albuminuria | 2.443 (0.551 to 10.825) | 0.240 | — | — |
| baPWVa (per 1 cm/s) | 1.001 (1.000 to 1.001) | 0.004 | 1.001 (1.000 to 1.001) | 0.001 |
| Medications | ||||
| aspirin use | 1.292 (0.561 to 2.974) | 0.547 | — | — |
| ACEI and/or ARB use | 0.381 (0.167 to 0.870) | 0.022 | — | — |
| β-blocker use | 0.719 (0.119 to 4.324) | 0.718 | — | — |
| calcium channel blocker use | 1.529 (0.672 to 3.478) | 0.311 | — | — |
| diuretic use | 0.392 (0.132 to 1.170) | 0.093 | — | — |
| statin use | 0.465 (0.167 to 1.294) | 0.142 | — | — |
| ESA use | 18.429 (6.615 to 51.348) | <0.001 | — | — |
Abbreviations are the same as in Table 1. −2 Log likelihood = 100.5; χ2 = 40.3; P <0.001.
a
Data were adjusted for mean arterial pressure.