Table 1.
Biochemical and hormonal changes in response to dDAVP administered alone (control period, day 4) or after 7-day pretreatment with amiloride (amiloride period, day 14) in 47 healthy patients on a high Na/low K diet
| Control Period (Day 4) | Amiloride (Day 14) | ||
|---|---|---|---|
| Plasma osmolality (mosmol/kg H2O) | Before dDAVP | 284 ± 4 | 283 ± 3 |
| After dDAVP | 285 ± 4 | 282 ± 4 | |
| Plasma sodium (mmol/L) | Before dDAVP | 139 ± 2 | 137 ± 2 |
| After dDAVP | 139 ± 3 | 137 ± 2 | |
| Plasma potassium (mmol/L) | Before dDAVP | 3.6 ± 0.2 | 4.1 ± 0.3 |
| After dDAVP | 3.6 ± 0.2 | 4.1 ± 0.3 | |
| Plasma creatinine (μmol/L) | Before dDAVP | 81 ± 10 | 81 ± 10 |
| After dDAVP | 81 ± 11 | 80 ± 10 | |
| Plasma active renin (pg/ml) | Before dDAVP | 13 (12, 15) | 43 (39, 48) |
| After dDAVP | 15 (14, 17)a | 51 (46, 57)a | |
| Plasma aldosterone (pg/ml) | Before dDAVP | 20 (16, 25) | 180 (159, 203) |
| After dDAVP | 16 (13, 19)a | 183 (165, 204) |
Data are mean ± SD or geometric mean (95% CI).
a
P < 0.001 after versus before dDAVP.