TABLE 3.

Primary structure activity relationships for MSNB analogs 30–36

IC₅₀ values were determined using data from two independent experiments in triplicate.

^a Competitive fluorescence polarization assay in the presence of TRβ-LBD (0.6 μm), T₃ (1 μm), and Texas Red-labeled SRC2–2 peptide (20 nm). The data were recorded after a 3-h incubation.

^b Percent efficacy is indicated within parentheses.