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Schematic illustration of distinct interactions between MAdCAM-1 and integrin α4β7 at different activation states. Integrin α4β7 at different activation states has distinct binding interfaces for the MAdCAM-1 CC′ and DE loops. A, binding of MAdCAM-1 to low-affinity (inactive) integrin α4β7. B, binding of MAdCAM-1 to high-affinity integrin α4β7 activated by physiological stimuli (talin or SDF-1α). C, binding of MAdCAM-1 to high-affinity integrin α4β7 activated by Mn2+.
