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. 2011 Feb 1;286(14):12429–12438. doi: 10.1074/jbc.M110.197467

FIGURE 5.

FIGURE 5.

Similar domain arrangement in the SR4-SR5-SH3 of plectin and the complex formed by βI-spectrin and ankyrin R. A, worm representation of the structure of the SR4-SR5-SH3 of plectin; the orientation is the same as in Fig. 1C. B, structure of the ZU5-ANK domain of ankyrin R bound to the SR14-SR15 of βI-spectrin (PDB code 3KBT); the SR13, which is present in the crystal structure of the complex but does not contact the ZU5-ANK domain, has been omitted. C, orthogonal views of the ankyrin/βI-spectrin and the plectin structures after superposition of the SR14 of βI-spectrin onto the SR4 of plectin. D, close-up view of the SH3/SR4 and ZU5-ANK/SR14 interfaces in plectin and the ankyrin/βI-spectrin complex, respectively. The side chain of Val-881 in the SH3 of plectin and Arg-948 in the ZU5-ANK domain occupy equivalent positions and are shown as sticks. For clarity, only a segment of the backbones around Val-881 and Arg-948 are shown.