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Schematic model of PDE4B and PDE4D cellular distribution and resulting pattern of cAMP accumulation. A, B, C, and D, cyclic AMP distribution in WT MEFs with no stimulation (A) and following Iso stimulation in WT (B), PDE4D−/− (C), and PDE4B−/− (D) MEFs. PDE4B is localized to a small portion of the cell membrane (<2% of the total cell volume). This compartment has limited equilibration with the cytosol. AR, adrenergic receptor.
