TABLE 2.

PI3K mediates BCR-induced targeting of RasGRP1 to the plasma membrane

	% of cells with detectable signal at plasma membranea αIgM		Signal intensity, plasma membrane/cytoplasmb + αIgM
	LY303511	LY294002	LY303511	LY294002
RG1	100	50	6.7 ± 2.5c	1.9 ± 0.6
TAPP1 PH	90	28	1.7 ± 0.2	1.1 ± 0.0

^a 200+ DT40 cells were scored for detectable concentration of GFP signal at the plasma membrane.

^b Signal intensities at plasma membrane and cytoplasm were determined as described under “Experimental Procedures.”

^c Values are the mean ± S.D.