Figure 3.

Binding of the D2 receptor antagonist [¹²⁵I]iodosulpiride to coronal sections of wild-type and Go−/− mouse brains. (A) Diagram showing location of coronal sections tested. (C Left) Annotation of anatomical landmarks present in the respective sections (42). (C Center and Right) Binding of 0.2 nM ¹²⁵I-sulpiride (30 min at room temperature) to D2 receptors in the respective sections as revealed by autoradiography. Note that there appears to be no significant difference between wild-type and Go−/− brains in the binding of a subsaturating concentration of the antagonist (0.2 nM).