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. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: Hepatology. 2011 Jan 10;53(2):649–660. doi: 10.1002/hep.24059

Fig. 3. Parenchymal cell-specific IRF3 deficiency is associated with decreased Type I IFN and IL-10 induction.

Fig. 3

Wild-type mice with transplanted WT bone marrow (WT/WT-BM), IRF3-deficient mice with transplanted wild-type bone marrow (IRF3-KO/WT-BM) and WT mice with transplanted IRF3-deficient bone marrow (WT/IRF3-KO) were fed Lieber DeCarli ethanol or control (pair-fed) diet and sacrificed after 4 weeks. Messenger RNA levels of (A) liver interferon β (IFN-β), interferon sstimulated gene 56 (ISG-56) and (C) interleukin 10 (IL-10) were analyzed by real-time PCR and normalized to 18s. Liver IL-10 protein levels were analyzed using immunoblot analysis (D). Values are shown as mean ± SEM fold increase over wild-type pair-fed control group (11-17 mice per group). Numbers in graphs denote p values. *) p < 0.05 vs. pair-fed wild-type mice; #) p < 0.05 vs. ethanol-fed wild-type mice.