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. Author manuscript; available in PMC: 2011 Apr 1.
Published in final edited form as: J Med Chem. 2011 Feb 4;54(5):1308–1313. doi: 10.1021/jm1013049

Scheme 1.

Scheme 1

Solid-Phase Synthesis of Compound 1 and Structures of PAR-2 Agonistsa

a (a) (i) Fmoc/tBu synthetic strategy; (ii) 10% piperidine in DMF, 2 + 20 minutes; (iii) HBTU coupling of 2-aminothiazole-4-carboxylic acid;

(b) (i) 91% TFA, 3% thioanisole, 3% 1,2-ethanedithiol, 3% water, 4 h; (ii) ether extraction; (iii) HPLC and SEC purifications.