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. Author manuscript; available in PMC: 2012 Jan 3.
Published in final edited form as: Life Sci. 2010 Nov 6;88(1-2):65–73. doi: 10.1016/j.lfs.2010.10.023

Fig. 5.

Fig. 5

Survival and apoptosis. Protein expression bands and densitometric analysis of the survival genes survivin, phosphorylated Akt/total Akt (top), phospho/non-phospho ERK 1–2 and bcl-2/bax (middle), and p38MAPK and PI3K/PTEN (bottom). Under hypoxia, there was a decrease of survivin and a mild increase in the phosphorylated Akt/total Akt ratio, changes that were prevented by HPC. Hypoxia also decreased the ratio of ERK 1–2 and increased the protein expression of bcl-2/bax. Lastly, hypoxia modulated the expression of p38MAPK and PI3K/PTEN. *p<0.05 compared to control and Hypoxia + HPC, ¥ p<0.05 compared to control.