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. Author manuscript; available in PMC: 2011 Apr 1.
Published in final edited form as: J Immunol. 2010 Mar 15;184(6):2743–2749. doi: 10.4049/jimmunol.0902937

Figure 1. Domain structures of TIM-1 and TIM-3.

Figure 1

The major structural domains of Tim-1 (left) and Tim-3 (right) are shown. The lettering on the IgV domains refers to the structural loops identified in the published crystal structures of this domain from the two proteins (41, 42). Major insertional polymorphisms for both mouse and human Tim-1 are indicated, as are the best-characterized point mutations (PM) of mouse Tim-3. Polymorphisms of human and mouse TIM’s have previously been reviewed in greater detail (12). Likely sites of O- and N-linked glycosylation in the mucin-like and stalk domains, respectively, are also shown. Possible sites of glycosylation within the IgV domains (41, 42) have been omitted for clarity.