Table I.
Selected antibodies to mouse and human TIM-1 that have been functionally characterized in the literature. Unless otherwise stated, the antibodies recognize murine Tim-1.
Tim-1 Antibodies | Epitope | Functional Effects | Refs. |
---|---|---|---|
3B3 | IgV | Activation; co-stimulation | (17) |
1H8.2 | Mucin/stalk (BALB/c only) |
Increased Th2 | (24) |
5D1.1 | Mucin/stalk (BALB/c only) |
Increased Th2 | (24) |
3A2.5 | Stalk | Decreased Th2 | (24) |
4A2.2 | IgV | Decreased Th2 | (24) |
1H9.9 | IgV | No apparent effects | (24) |
RMT1-10* | IgV | Inhibition of T cell responses | (25, 50, 51) |
3D1 (human) | IgV | Blocks HAV and PS binding | (43, 52) |
This Tim-1 antibody should not be confused with a commercially available antibody with the same name