Table II.
Selected antibodies to mouse and human TIM-3 that have been functionally characterized in the literature. Unless otherwise stated, the antibodies recognize murine Tim-3.
| Tim-3 Antibodies | Epitope | Functional Effects | Refs. |
|---|---|---|---|
| 8B.2C12 | ? (BALB/c ≫ BL/6) | Increased Th1 | (14) |
| 5D12 | IgV | Increased Th1 | (36) |
| 8H7 | ? | Increased Th1 / Decreased Th2 | (27, 28) |
| RMT3-23 | ? | Increased Th1 | (30) |
| 2E2 (human) | ? | Reversal of CD8+ exhaustion (HIV) Increased Th1/Th17 cytokines |
(33, 34 |
| 1G5 (human) | ? | Reversal of T cell non- responsiveness (HCV) |
(35) |