Table 1.
Double-unit CBT patient and graft characteristics
| Characteristic (n = 84) | Value |
|---|---|
| Median age (range), y | 36.5 (0.9-66) |
| Median weight (range), kg | 68 (7-117) |
| Diagnosis, n = 84 (%) | |
| Acute myeloid leukemia | 25 (30) |
| Acute lymphoblastic leukemia | 17 (20) |
| Other acute leukemia, MDS, or CML | 6 (7) |
| Lymphoma or chronic lymphocytic leukemia | 36 (43) |
| Preparative regimen, n = 84 (%) | |
| Myeloablative | 61 (73) |
| TBI-based | 49 (58) |
| Chemotherapy-based | 12 (14) |
| Nonmyeloablative | 23 (27) |
| Unit-recipient HLA match, n = 168 (%)* | |
| 6/6 (range 4/10 to 9/10) | 6 (4) |
| 5/6 (range 4/10 to 9/10) | 94 (56) |
| 4/6 (range 2/10 to 7/10) | 68 (40) |
| Median cell and CFU doses after thaw, n = 168 units (range) | |
| Infused TNC × 107/kg | |
| Larger unit, n = 84 | 2.5 (1.4-11.3) |
| Smaller unit, n = 84 | 1.9 (0.9-7.1) |
| Infused CD34+ × 105/kg | |
| Larger unit, n = 84 | 1.14 (0.26-6.42) |
| Smaller unit, n = 84 | 0.61 (0.08-1.52) |
| Infused CD3+ × 106/kg | |
| Larger unit, n = 84 | 4.3 (1.3-12.0) |
| Smaller unit, n = 84 | 3.0 (0.32-10.6) |
| Infused CFU × 104/kg | |
| Larger unit, n = 84 | 4.49 (0.59-15.76) |
| Smaller unit, n = 84 | 2.15 (0.01-10.01) |
| Percentage of CD34+ cell viability after thaw, n = 168 (range) | 92 (34-99) |
CML indicates chronic myelogenous leukemia; MDS, myelodysplasia; and TBI, total body irradiation.
*
The number of units (%) with a unit-recipient HLA match of 6/6, 5/6, and 4/6 are shown with the range of HLA match of these units to the recipient at high resolution.