Figure 4.

No difference in magnitude of expression change in adjacent normal tissue and in tumor tissue for genes near tumor integrants and genes distal to tumor integrants. Plots of log₂-transformed gene expression levels in tumor tissue versus log₂-transformed gene expression levels in adjacent normal for mice (A) M24, (B) M48, (C) M50, and (D) M60. Gene expression levels were determined from microarray with the use of the Mouse Gene 1.0ST Affymetrix chip. Red dots indicate the closest gene to an integrant cloned from tumor tissue, and black dots indicate all other genes on the array. P value from the Mann-Whitney U test compared the change in expression for genes near integrants with all other genes.