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. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: Mol Cancer Res. 2010 Dec 14;9(2):195–202. doi: 10.1158/1541-7786.MCR-10-0363

Figure 5.

Figure 5

GSH blocks GT-094-induced growth inhibition and apoptosis. Inhibition of RKO (A) and SW480 (B) cell growth by GT-094 blocked by GSH. Cells were treated with 50 μmol/L GT-094 or 5 mmol/L GSH alone or in combination for 24 h, and cell numbers were determined as described in the Materials and Methods. Significant (p<0.05) inhibition by GT-094 (*) or reversal of this effect by GSH (**) are indicated. Induction of apoptosis by GT-094 ± GSH in RKO (C) and SW480 (D) cells. Cells were treated with GT-094 ± GSH for 24 h, and apoptosis was determined by TUNEL staining as described in the Materials and Methods. Significant (p<0.05) induction of apoptosis by GT-094 (*) and inhibition after cotreatment with GSH (**) are indicated.