Table 2.
Homology of MOR, DOR, and KOR receptors within different vertebrate speciesa
| Species | MOR vs. DOR | MOR vs. KOR | DOR vs. KOR | Mean (S.E.M.)b |
|---|---|---|---|---|
| Identity | ||||
| Zebrafish | 68 | 62 | 68 | 66.0 (2.0) |
| Frog | 73 | 65 | 63 | 67.0 (3.1) |
| Rat | 66 | 61 | 61 | 62.7 (1.7) |
| Mouse | 61 | 60 | 61 | 60.7 (0.3) |
| Human | 62 | 60 | 59 | 60.3 (0.9) |
| Similarity | ||||
| Zebrafish | 80 | 78 | 82 | 80.0 (1.2)** |
| Frog | 85 | 81 | 77 | 81.0 (2.3)* |
| Rat | 76 | 75 | 74 | 75.0 (0.6) |
| Mouse | 71 | 75 | 73 | 73.0 (1.2) |
| Human | 73 | 73 | 72 | 72.7 (0.3) |
a
Percent identity and similarity determined by BLAST-P (version 2.2.4) at NCBI website (WWW.NCBI.NLM.NIH.GOV/BLAST) settings: matrix=Blossum62, gap open=11, gap extension=1, x dropoff=50, expect=10.00, wordsize=3, and filter off (from Stevens and Brasel, in preparation).
b
Standard error of the mean.
*
Significantly different than rat, mouse, and human mean values (p<0.05, one-way ANOVA followed by post-hoc Newman–Kuels test).