Figure 1. Inflammatory responses enhance tumor-selective accumulation of radiolabeled antibodies.

(A) BALB/c mice bearing subcutaneous CT26 tumors were administered C. novyi-NT spores plus ¹²⁵I-labeled liposomase antibody, CD20 antibody, or an IgG control antibody by tail vein injection. The animals were imaged by SPECT/CT 24 hours thereafter. Tumor (Tu), thyroid (Th) and bladder (Bl) are indicated. (B, C) Tumor-bearing mice were administered ¹²⁵I-labeled IgG plus C. novyi-NT spores or TNF-α by tail vein injection. For biodistribution analysis (B), mice were sacrificed 48 hours later and percent injected dose per gram of tissue (ID%/g) was determined. Means and s.d. are shown. For imaging study (C), SPECT/CT images were taken at the indicated time points after the injections. Tumor (Tu) is indicated.