Figure 4. Vascular effect of TNF-α on a brain tumor model.

(A) C57BL6 mice bearing orthotopic brain tumors were treated with a single dose of the indicated therapeutic agents 12 days after tumor implantation. The number of animals used in each experimental arm and P values between arms are shown. (B) SPECT-CT images were obtained 48 hours following the indicated treatments, which were performed 25 days following tumor implantation. Transverse, coronal, and sagittal images are shown and tumors indicated by the arrowheads. In this particular animal, two tumor nodules developed along the injection track and both showed tumor accumulation of ¹²⁵I-labeled SSLs when TNF-α was co-administered.