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. 2011 Mar 7;121(4):1624–1635. doi: 10.1172/JCI42040

Figure 3. Tie1 heterozygosity reduces advanced-stage atherosclerosis burden.

Figure 3

(A and B) Quantitation of Tie1 levels in Tie1+/– mice of (A) aortic endothelia by RT-PCR (49% reduction, P < 0.01, n = 4) and (B) pulmonary tissue by Western blot (40% suppression, P < 0.05). (C and D) Effect of reduced Tie1 expression on atherosclerosis. (C) Representative images of Sudan IV–stained aorta (aortic arch and thoracic and abdominal aorta) from 49-week-old Tie1+/+;Apoe–/– and Tie1+/–;Apoe–/– mice. (D) Atherosclerotic lesion area in Tie1+/+;Apoe–/– versus Tie1+/–;Apoe–/– mice at 12, 18, 24, and 49 weeks of age. Data points denote individual animals; horizontal bars indicate group average. *P < 0.05; **P < 0.01.