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. 2011 Mar 14;121(4):1549–1560. doi: 10.1172/JCI44539

Figure 1. Reduced susceptibility of CD4+ T cells from elite controllers to HIV-1 infection.

Figure 1

(A) p24 antigen production in activated CD4+ T cells from elite controllers (EC), viremic controllers (VC), HIV-1–negative persons (HIV-), and HIV-1 progressors (Prog) after exogenous HIV-1 infection with the X4-tropic primary isolate 92HT599 and the primary R5-utilizing strain 91US056. Data were obtained on day 7 after infection; similar patterns of p24 antigen production were observed on days 3 and 5 after infection (Supplemental Figure 1). Baseline p24 levels in autologous cells without exogenous HIV-1 infection were subtracted as background. Significance was tested using Mann-Whitney U test. (B–E) Flow cytometric assessment of HIV-1 replication in activated CD4+ T cells from elite controllers and HIV-1–negative persons on day 4 after infection with GFP-encoding X4- and R5-tropic HIV-1 isolates. (B and D) Representative flow cytometry dot plots from 1 elite controller and 1 HIV-1–negative person. Percentages indicate the respective proportions of gated GFP+ CD4+ cells. (C and E) Proportion of GFP+ CD4+ T cells from the indicated subjects. Bounds of boxes denote interquartile range; lines within boxes denote median; whiskers indicate range.