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. 2011 Mar 14;121(4):1549–1560. doi: 10.1172/JCI44539

Figure 3. Upregulation of p21 expression in CD4+ T cells from elite controllers.

Figure 3

(A) Relative CDKN1A mRNA expression in sorted HLA-DR– and HLA-DR+ CD4+ T cells from the indicated groups. (B) Correlation between relative CDKN1A mRNA expression in HLA-DR– and HLA-DR+ CD4+ T cells and susceptibility of CD4+ T cells to HIV-1 infection, as determined by p24 production 7 days after infection of in vitro activated cells with R5-tropic HIV-1. Data from elite controllers, viremic controllers, HIV-1–negative persons, and HIV-1 progressors were included. Pearson’s correlation coefficient is shown. (C) Western blots reflecting p21 and β-actin protein expression in CD4+ T cells from the indicated cohorts. (D) Quantitative p21 protein expression in CD4+ T cells from indicated study patients. (A, B, and D) Statistical comparison was performed using Student’s t tests.