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. 2011 Mar 1;121(4):1585–1595. doi: 10.1172/JCI44630

Figure 1. Six1–/–Eya1–/– mutants phenocopy features of human del22q11 syndromes.

Figure 1

(A–F) Gross morphological defects of the OFT and great arteries of newborn mutants (B–F) versus WT control (A). (G–J) H&E histological staining of sectioned hearts revealed VSD and dysmorphology of the outflow valves in a Six1–/–Eya1–/– mutant (I and J) compared with Six1+/–Eya1+/– control (G and H). Ao, aortic artery; BCA, brachiocephalic artery; dA, descending aorta; DLCC, duplicated left common carotid artery; LCC, left common carotid artery; LSC, left subclavian artery; p, pulmonary artery; RCC, right common carotid artery; RRSA, retroesophageal right subclavian artery; RSC, right subclavian artery; V, ventricle; VR, vascular ring. Asterisks denote interrupted aortic arches. Original magnification, ×50 (G and I); ×80 (H and J).